To allow dental implant placement in the posterior maxilla, it is sometimes necessary to increase the height of the residual alveolar bone of the maxillary sinus floor by undertaking a sinus lift procedure. The historical material of choice has been autogenous bone (AB), but this can lead to donor-site morbidity following harvesting. To simplify this process of sinus augmentation, several substitute materials have been studied, such as xenografts in the form of deproteinised bovine bone, synthetic grafts, growth factors, and platelet concentrates. There have been three recent systematic reviews utilising standard pairwise meta-analyses to investigate the efficacy of these biomaterials as a substitute for AB (Corbella et al., 2016; Danesh-Sani et al., 2017; Ting et al., 2017). The authors chose to undertake a Bayesian network meta-analysis (NMA) to evaluate and rank all these materials simultaneously in their capacity to form new bone. (Trimmel et al., 2021)
The study protocol was registered in PROSPERO (International Prospective Register of Systematic Reviews) and followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis for Network Meta-analysis (PRISMA-NMA) guidelines (Hutton et al., 2015). A systematic search for suitable randomised control trials (RCTs) was performed in the Cochrane Library (CENTRAL), EBSCO, Embase, MEDLINE (via PubMed), and Web of Science Core Collection electronic databases with records published up to October 1, 2019. The risk of bias was assessed using the Cochrane Risk of Bias Tool.
The Bayesian approach for NMAs describes the range and probability of the parameter of interest (e.g., treatment effect here being bone % bone regeneration). The posterior distribution produced by this method predicts the new range and probability of plausible values for these parameters with the representation of uncertainty in the form of a 95% credibility interval. The interventions were ranked by their posterior probability by calculating the surface under the cumulative ranking (SUCRA) curve values.
- 34 RCTs (842 maxillary sinus augmentations) with an average healing period of 5–8 months were included in the NMA. 31 were two-arm studies, and 3 were three-arm studies.
- There were 28 treatment options, 378 possible pairwise comparisons, and 31 pairwise comparisons using direct data.
- The overall assessment for risk of bias showed low risk in 5 studies, unclear risk in 20 studies, and high risk in 9 studies.
- There were significant differences favouring the bovine bone + bone marrow concentrate (BMC) composite graft and the biodegradable copolymer; and between the bovine + BMC composite graft and the allograft.
- From the 376 pairwise comparisons, no significant differences were detected, leading to a rejection of the null hypothesis that AB alone is the most favourable material for bone regeneration.
- The SUCRA ranking probability for the most effective bone grafting material for new bone regeneration:-
|Top Five Grafting Materials||SUCRA ranking|
|Bovine xenograft + bone marrow concentrate (BMC)||81%|
|Bovine xenograft + platelet-rich plasma (PRP)||77%|
|Bioactive glass ceramic + autologous bone 1:1||70%|
|Nanocrystalline hydroxyapatite in silica gel||70%|
|Autologous bone graft||57%|
The authors concluded:-
The results of the present NMA suggest that the use of biomaterials does not result in a statistically significant difference in the rate of NB formation compared to AB alone as grafting material. However, their use can significantly reduce the amount of AB graft required for MSA, resulting in a less invasive surgical intervention and shorter surgical time. The combination of biomaterials with AB or autologous cell concentrates, such as BMC, PRP, and platelet-rich fibrin, represents a feasible alternative for AB substitution to achieve high NB formation. The superiority of AB compared to biomaterials for MSA in a healing time frame of 5–8 months cannot be justified.
Network meta-analyses are highly complex statistical tools to evaluate multiple treatment options. This complexity can limit the strength and certainty of the inferences produced even when the NMA is well done, as in this case. In a two-part paper by Foote, Chaudhry and co-workers, they outline a practical guide on interpreting NMAs (Foote et al., 2015; Chaudhry et al., 2015). It should be noted that even though this NMA had a high number of treatment nodes, it was a sparse network with a network density of about 10%, whereas a full connected (dense) network would achieve 100%. The sparsity of connections increases the reliance on indirect evidence and the effects of heterogeneity within the included studies, leading to extremely wide confidence/credibility intervals and questionable results (Brignardello-Petersen et al., 2019). To explore this potential problem, the primary data in Table 2 of Trimmels paper was extracted and reanalysed using the R package called “BUGSnet” (Bayesian inference Using Gibbs Sampling to conduct a Network meta-analysis) in R (Béliveau et al., 2019). The initial reanalysis duplicated Trimmels results, as can be seen in the netplot (Figure 1).
Figure 1. Netplot of Trimmel original data.
The material and methods section of the original paper mentioned that each intervention would be presented compared to a placebo in a forest plot; however, the forest plot was not shown in the paper. In the reanalysis, the forest plot is given below. It clearly shows the very wide credibility intervals. Almost all the treatment options cross the null effect line, confirming the problems created by incorporating many small poorly networked studies and the resultant indirect estimates the model generates (Figure 2.).
Figure 2. Forest plot relative to autogenous bone
To explore this further, the simplest method was to undertake a sensitivity meta-analysis and remove those studies considered to be at high risk of bias. These studies would be the most likely to result in misleading results (Chaudhry et al., 2015). The 9 papers the authors considered to be a high risk of bias were removed from the NMA database, and 2 further papers that appeared to share a control group. The rankings were then recalculated and presented alongside the original ranking data to observe any changes. The reanalysis removed 3 treatments from the ranking (autogenous bone plus autologous platelet concentrate, bovine plus bone marrow aspirates, and porcine bone), plus bone marrow concentrate was dropped 18 places from 81% to 40%. The top five highest-ranking treatments now include bovine bone mixed with autologous bone, bovine bone plus platelet-rich fibrin (PRF), and biphasic calcium phosphate (HA/β-TCP = 60/40) combined with fibrin sealant (FS). (Table 1.)
Table 1. Change in top 5 ranked augmentation materials.
|Rank||Sensitivity meta-analysis||Score||Original meta-analysis||Score|
We could conclude that the sensitivity analysis confirmed the authors finding that autologous bone did not show superiority to composite grafting material. Significantly, however, the ranking of those materials changes at the extremes, with the first six highest rankings being substantially downgraded and three treatments being removed from the meta-analysis altogether (Figure 3).
Figure 3. Change in SUCRA scores with sensitivity analysis.
In summary, both the researcher and the reader must exercise caution when undertaking a network meta-analysis. Leaving aside the issue of transitivity assumptions, consistency and statistical complexity, network analysis will not eliminate the problems associated with combining multiple small, severely underpowered studies that could be potentially at high risk of bias. To quote Foote and co-authors: –
Assessing the credibility of the methodology is an important first step in critically appraising an NMA. As with conventional systematic reviews, assessing credibility involves evaluating the article for a sensible research question, an exhaustive search, reproducible selection and assessment of articles, presenting clinically relevant results, and addressing certainty in effect estimates (Foote et al., 2015).
Trimmel, B., Gede, N., Hegyi, P., et al. 2021. Relative Performance of Various Biomaterials Used for Maxillary Sinus Augmentation: A Bayesian Network Meta‐Analysis. Clinical Oral Implants Research, 32, 135-153.
Béliveau, A., Boyne, D. J., Slater, J., et al. 2019. Bugsnet: An R Package to Facilitate the Conduct and Reporting of Bayesian Network Meta-Analyses. BMC Medical Research Methodology, 19.
Brignardello-Petersen, R., Murad, M. H., Walter, S. D., et al. 2019. Grade Approach to Rate the Certainty from a Network Meta-Analysis: Avoiding Spurious Judgments of Imprecision in Sparse Networks. J Clin Epidemiol, 105, 60-67.
Chaudhry, H., Foote, C. J., Guyatt, G., et al. 2015. Network Meta-Analysis: Users’ Guide for Surgeons: Part Ii – Certainty. Clinical Orthopaedics & Related Research, 473, 2172-2178.
Corbella, S., Taschieri, S., Weinstein, R., et al. 2016. Histomorphometric Outcomes after Lateral Sinus Floor Elevation Procedure: A Systematic Review of the Literature and Meta-Analysis. Clinical Oral Implants Research, 27, 1106-1122.
Danesh-Sani, S. A., Engebretson, S. P. & Janal, M. N. 2017. Histomorphometric Results of Different Grafting Materials and Effect of Healing Time on Bone Maturation after Sinus Floor Augmentation: A Systematic Review and Meta-Analysis. Journal of Periodontal Research, 52, 301-312.
Foote, C. J., Chaudhry, H., Bhandari, M., et al. 2015. Network Meta-Analysis: Users’ Guide for Surgeons: Part I – Credibility. Clinical Orthopaedics & Related Research, 473, 2166-2171.
Hutton, B., Salanti, G., Caldwell, D. M., et al. 2015. The Prisma Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta-Analyses of Health Care Interventions: Checklist and Explanations. Ann Intern Med, 162, 777-784.
Ting, M., Rice, J. G., Braid, S. M., et al. 2017. Maxillary Sinus Augmentation for Dental Implant Rehabilitation of the Edentulous Ridge: A Comprehensive Overview of Systematic Reviews. Implant Dent, 26, 438-464.
There has been a considerable amount of literature developed over the Coronavirus CoV-2 pandemic regarding the dental profession, aerosol generating procedures (AGP), airborne spread of the virus and the need for enhanced personal protective equipment (PPE).Though there is evidence that dental AGPs cause significant environmental contamination there is very little evidence linking this to direct infection of staff or patients (HPS, 2020).
To reduce the potential risk of infection via the airborne route most national and international regulations (Clarkson et al., 2020) require that dental teams wear Face Filtering Piece level respiratory protection (FFP2/FFP3) in addition to standard PPE when performing AGPs. Following the SARS-Cov-1 outbreak in Toronto, Canada, powered air-purifying respirators (PAPRs) superseded the use of FFP respirators in the respiratory PPE protocols (Peng et al., 2003) however there is no mention of their existence as an alternative to FFP3 respirator in the PPE guidance from the Office of the Chief Dental Officer (England) (OCDO, 2020). This review is important due to limited information available regarding the practical efficacy between FFP2/FFP3 and PAPRs in the clinical environment.
This systematic review was reported according to the standards for the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), and the protocol was prospectively registered with the International Register of Systematic Reviews (PROSPERO). Searches were undertaken using the electronic databases: Medline; Embase; Cochrane Library (Cochrane Database of Systematic Reviews and CENTRAL). Grey literature was sought through: Google Scholar, OpenGrey, and GreyNet. Searches were repeated up to June 2020, and only English language studies were included.
Studies were screened by two reviewers. Risk of bias in randomized controlled studies was assessed using the Cochrane Risk of Bias tool, and the ROBINS-I (Risk of Bias in Non-randomized Studies of Interventions) tool to assess the risk of bias in non-randomized studies. Quality of evidence was classified according to Grading of Recommendations, Assessment, Development and Evaluation (GRADE). Due to the heterogeneity of the small number of studies a narrative review was undertaken.
- 10 studies fulfilled the inclusion criteria out of a total of 690.
- There was no difference in the primary endpoint of COVID-19 infection in respective observational studies in the airway proceduralists utilizing PAPR versus other protective respiratory equipment.
- Healthcare workers reported Improved comfort with regards to heat tolerance and visibility with PAPR technology.
- Decreased effort was needed to maintain the work of breathing compared to conventional filtering face pieces.
- Lower contamination rates of skin and clothing in simulation studies of participants utilising PAPRs.
- Decrease in audibility and communication difficulties due to increased weight of the equipment and noise generated by positive airflow.
The authors concluded: –
Field observational studies do not indicate a difference in healthcare worker infection utilizing PAPR devices versus other compliant respiratory equipment. Greater heat tolerance accompanied by lower scores of mobility and audibility in PAPR were identified. Further pragmatic studies are needed in order to delineate actual effectiveness and provider satisfaction with PAPR technology.
This was a well conducted systematic review considering the limitation in the number of studies. Due to the global nature of the pandemic more papers could possibly have been identified if the authors had not restricted the language search. There would appear to be numerous advantages identified in this review regarding the use of PAPRs such as increased assigned protection factors (APF >25), inbuilt eye protection, reusable, they don’t need fit testing, improved heat tolerance and comfort if worn for longer than 1 hour, and they can be worn without limiting facial hair.
Limitations include challenges in verbal communication due to the hum of the motor, maintenance and battery life, decontamination after use, and cost. Given the lack of demonstrable advantage in terms of infection prevention, institutional decision makers may be applying a pragmatic choice to use FFP3 over PAPR respirators, however there may be considerable physical and financial advantage for health care workers and dental staff who are required to work for extended periods.
Use of Powered Air-Purifying Respirator (PAPR) by healthcare workers for preventing highly infectious viral diseases -a systematic review of evidence. Ana Licina, Andrew J Silvers, Rhonda Stuart. medRxiv 2020.07.14.20153288;
CLARKSON, J., RICHARDS, D. & RAMSAY, C. 2020. Aerosol Generating Procedures and their Mitigation in International Dental Guidance Documents – A Rapid Review.
OCDO. 2020. Standard operating procedure Transition to recovery first published 4th June.[Online]. Accessed 1st Aug 2020].
PENG, P. W., WONG, D. T., BEVAN, D. & GARDAM, M. 2003. Infection control and anesthesia: lessons learned from the Toronto SARS outbreak. Canadian Journal of Anesthesia, 50, 989-997.